They work very well on fleece, but not the very thick/fuzzy material, they will stick but will come off in the wash. The soft baby blanket type fleece is good. I have never used an applicator, but many do and as Coack Kelli mentioned, it can be time consuming. I posted a comment in the "show off your Bow D" thread explaining how to do it with an iron. this too is time consuming, but less time than the applicator.
Basically print out your design in a mirror image or trace it on the backside of the page so that it is backward. Get some application tape and place it sticky side up on your design, then use twizers to apply your stones over your design. Stones must be grey/black side up, sparkly side down on the sticky transfer tape. When you are finished you press with a regular iron. NO STEAM!. Hold the iron in one place over the design and push down as hard as you can and hold it for at least 30 seconds. Do this twice on the top then turn the material and repeat on the back. You will need to use a paper towel between your iron and design/fabric so as to not burn the material.
Hope this helps. Good luck. Your firends will love the blankets. I made a few for my daughter. she personalizes them for her friends for birthday presents.