Hmmm... here's my two cents and you can take it however you want - I know I'm a tad young.
You seem very focused on what she thinks. Sometimes people are just unsatisfied with whatever anyone does. You could cure cancer and she'd still find a way to have a problem with it. You gotta ignore them. I think the sooner you find a way to deal with her/them, the sooner you will be happy with your job. I really like what
@Pebbles49 said, the part you bolded. Find things that help you improve your skill set for your position - things that don't have anything to do with her. Find things that you can look back on and say "wow, that was a challenge but look what I learned from it, look how I grew, and look how it can benefit me in my job for the future," regardless of this lady's attitude towards you. Stop looking for her approval. Learn to pat your own self on the back if no one else will. It's really hard but I swear, if you can find a way to ignore her and focus on ways to better yourself at work, people will notice just like they did at your old job. It might take a little time.
That being said, it sounds like you miss the familiarity of your old job; you were comfortable there. But like you said, it was grunt work and it doesn't sound like it's anything that would expand your abilities. You should use the praises you got at your old job as encouragement for yourself at your new job. People noticed how hard you worked and how good you were. It sounds like now you have more responsibilities and a higher bar has been set for you. If you could prove yourself at your old job, you can prove yourself at your new job. From what you posted on here, this job sounds like a big challenge - but a good challenge - and if you can overcome these small obstacles (mainly this lady and her attitude) then I think you'll see them same successes you had at your old job. And you'll be able to look back and see a lot of self-growth in yourself that will only benefit your job.
I think staying and following through is the hardest choice but the better choice. This job sounds like a great opportunity for you and where you want to be heading. And it might get tougher before it gets easier. But remember, you control your happiness there - not her.